Risk Assessment of Depression amongst Women during Menopause before and during the COVID-19 Pandemic.

During menopause, the risk of depression is 2-5 times greater than pre- or post-menopause. To assess the risk of depression amongst menopausal women in 2006, compared with 2021 (i.e., during the COVID-19 pandemic), we recruited female volunteers at least 40 years old to complete the menopause rating scale (MRS), the Blatt-Kupperman menopausal index (BKMI), and the Beck depression inventory. Compared with 2006, in 2021, the number of participants who experienced mild, moderate, and severe menopausal symptoms rose by 8%, 1.9%, and 3.2%, respectively. Moreover, the frequency of using hormone replacement therapy rose by 5.1%, feelings of mistrust by 16%, feelings of guilt by 11%, disposition to cry by 25%, mood swings by 12%, and suicidal ideation by 9%, whilst the average body weight and body mass index fell by 5.1 kg and 2.3%, respectively. In 2006 and 2021, 46.3% and 59.3% of participants experienced moderate depression, whereas 3.0% and 5.2% experienced severe depression. The number of participants who denied needing support during menopause decreased by 14.6%, whereas the demand for support from husbands and friends increased by 18.3% and 9.8%, respectively. In 2021, the number of participants who experienced menopausal symptoms, a loss of trust, self-blame, a tendency to cry, mood swings, suicidal ideation, and anxiety also increased compared with 2006, whilst the number of participants without depressive symptoms decreased, but with suspected mild or severe depression increased. Last, menopausal complaints caused an increase in depressive mood in 2021, as evaluated using the BKMI and MRS.

Is SARS-CoV-2 a Risk Factor of Bipolar Disorder?-A Narrative Review.

For 2.5 years we have been facing the coronavirus disease (COVID-19) and its health, social and economic effects. One of its known consequences is the development of neuropsychiatric diseases such as anxiety and depression. However, reports of manic episodes related to COVID-19 have emerged. Mania is an integral part of the debilitating illness-bipolar disorder (BD). Due to its devastating effects, it is therefore important to establish whether SARS-CoV-2 infection is a causative agent of this severe mental disorder. In this narrative review, we discuss the similarities between the disorders caused by SARS-CoV-2 and those found in patients with BD, and we also try to answer the question of whether SARS-CoV-2 infection may be a risk factor for the development of this affective disorder. Our observation shows that disorders in COVID-19 showing the greatest similarity to those in BD are cytokine disorders, tryptophan metabolism, sleep disorders and structural changes in the central nervous system (CNS). These changes, especially intensified in severe infections, may be a trigger for the development of BD in particularly vulnerable people, e.g., with family history, or cause an acute episode in patients with a pre-existing BD.

Impact of the Pandemic on Selected Aspects of Health-Promoting Attitudes in 2020-2021: A Cross-Sectional Study.

Introduction: In the face of the COVID-19 pandemic, people began to change both their health-promoting and anti-health behaviors. Aim of the Paper: To assess the impact of the pandemic on selected health-promoting attitudes. Methods: The cross-sectional study was conducted from March 2020 to September 2021. We have used the author's survey questionnaire and the standardized Wellness Behaviors Inventory (WBI). The questionnaires were given to respondents in paper versions to fill it. Results: The study group included 600 urban residents aged 32-73. Based on the opinions of the respondents, during the pandemic, the following activities increased the most: hand washing (93.3%), eating sweets and snacks (80%), and surfing the Internet (60%). An increase in drug/legal use was reported by 13.3%, with no indication of a decrease or no change in consumption of the above. The overall WBI index for all subjects before the pandemic was 81.3 ± 20.2 points, and the increase significantly (p < 0.001) during the pandemic was 87.7 ± 16.7 points. In addition, an increase in preferred eating habits was found (from 19.5 ± 6.4 to 21.1 ± 6.9 points; p < 0.001), preferred prophylactic behaviors (from 21.1 ± 6.0 to 22.7 ± 5.2 points; p < 0.001) and level of presented health practices during the pandemic (from 20.3 ± 5.1 to 24.7 ± 2.7 points; p < 0.001), and a decrease significantly (p < 0.001) in the degree of positive mental attitude (from 20.3 ± 5.4 points to 19.3 ± 4.9 points). Conclusions: Respondents generally rated their own and their family's health as worse during the pandemic period, and this trend continued when broken down by gender, cohabitant, place of residence, and education. According to the largest group of respondents, the frequency of handwashing, eating sweets and snacks, surfing the Internet, and using drugs/legal highs increased the most during the pandemic. The overall WBI index for all respondents before and during the pandemic was slightly higher during the pandemic period. Monitoring health behavior during a pandemic is essential for prevention and health care institutions. Further studies are needed to assess the long-term impact of the pandemic on pro-and anti-health behavior of people.

Impact of the Pandemic on Selected Aspects of Health-Promoting Attitudes in 2020–2021: A Cross-Sectional Study

Introduction In the face of the COVID-19 pandemic, people began to change both their health-promoting and anti-health behaviors. Aim of the Paper To assess the impact of the pandemic on selected health-promoting attitudes. Methods The cross-sectional study was conducted from March 2020 to September 2021. We have used the author's survey questionnaire and the standardized Wellness Behaviors Inventory (WBI). The questionnaires were given to respondents in paper versions to fill it. Results The study group included 600 urban residents aged 32–73. Based on the opinions of the respondents, during the pandemic, the following activities increased the most: hand washing (93.3%), eating sweets and snacks (80%), and surfing the Internet (60%). An increase in drug/legal use was reported by 13.3%, with no indication of a decrease or no change in consumption of the above. The overall WBI index for all subjects before the pandemic was 81.3 ± 20.2 points, and the increase significantly (p < 0.001) during the pandemic was 87.7 ± 16.7 points. In addition, an increase in preferred eating habits was found (from 19.5 ± 6.4 to 21.1 ± 6.9 points;p < 0.001), preferred prophylactic behaviors (from 21.1 ± 6.0 to 22.7 ± 5.2 points;p < 0.001) and level of presented health practices during the pandemic (from 20.3 ± 5.1 to 24.7 ± 2.7 points;p < 0.001), and a decrease significantly (p < 0.001) in the degree of positive mental attitude (from 20.3 ± 5.4 points to 19.3 ± 4.9 points). Conclusions Respondents generally rated their own and their family's health as worse during the pandemic period, and this trend continued when broken down by gender, cohabitant, place of residence, and education. According to the largest group of respondents, the frequency of handwashing, eating sweets and snacks, surfing the Internet, and using drugs/legal highs increased the most during the pandemic. The overall WBI index for all respondents before and during the pandemic was slightly higher during the pandemic period. Monitoring health behavior during a pandemic is essential for prevention and health care institutions. Further studies are needed to assess the long-term impact of the pandemic on pro-and anti-health behavior of people.

The Influence of the COVID-19 Pandemic on Women's Feelings during a Hospital Stay.

Introduction: The COVID-19 (coronavirus disease 2019) affected individuals and society and caused disruption, anxiety, stress, and loneliness. Being hospitalized during the pandemic increase a patient's negative feelings. This study aimed to evaluate the impact of the COVID-19 pandemic on patients' feelings (loneliness, depression, hope, self-efficacy) during a hospital stay. Materials and methods: This study included 207 women, aged from 15 to 83 years (55 ± 21.2) that were hospitalized during the pandemic in Bialystok, Lomza, and Biala Podlaska, Poland at internal medicine departments. The main reasons for hospitalization were cardiovascular diseases, abdominal pain, chronic obstructive pulmonary disease, pneumonia, diabetes, and unknown fever. Respondents were asked to complete the following questionnaires: Sense of Loneliness (the DJGLS), Depression Beck Inventory (BDI), Basic Hope (BHI-12), and Self-Efficacy (GSES). Results: Most of the studied group of women had an average sense of loneliness. A greater sense of loneliness was found among hospitalized women living in the countryside-the lowest sense of loneliness and depression was among women with higher education and the highest sense of effectiveness. One-third of respondents had a moderate degree of depression. Of the respondents, 39% had a relatively high level of basic hope. The assessment of self-efficacy demonstrated that 52% of the respondents showed a high sense of self-efficacy, an average sense of self-efficacy was shown by 35.5% of the respondents, and a low sense of self-efficacy was shown by 12.6% of the respondents. Conclusions: Numerous hospitalized women during the COVID-19 pandemic, despite experiencing moderate depression, had an average sense of loneliness and a high level of hope and self-efficacy.

Selected Aspects of the Mental Functioning of Women After Childbirth in a Hospital During a Pandemic.

Introduction: The COVID-19 pandemic is stressful for pregnant women, their families, and their unborn baby. Aim of the Study: The study aimed to assess the impact of a pandemic on the mental state of women after childbirth. Material and Methods: The study included 363 women hospitalized after delivery. The study used a diagnostic survey method using the proprietary questionnaire and the Family Affluence Scale (FAS), Edinburgh Postnatal Depression Scale (EPDS), Jong Gierveld Loneliness Scale (DJGLS), The Basic Hope Inventory (BHI-12), and General Self Efficacy Scale (GSES). Results: Suspicion of postpartum depression was found in 109 women (mean: 15.28 ± 2.22)-group I, and no suspicion of it in 254 subjects (mean: 6.03 ± 2.63)-group II. Mean values of the sense of loneliness in group I (27.11 ± 6.00) were higher than in group II (21.35 ± 7.02), and the basic hope-BHI-12, in group I-lower (27.92 ± 5.14) than in group II (31.75 ± 4.97). In the Generalized Own Efficacy Scale, the group I obtained lower mean values (28.07 ± 4.86 points and 5.87 ± 1.96 points) than group II (30.97 ± 3.77 points and 6.02 ± 1 points, 38 sten). Conclusions: As much as 30% of the respondents showed a risk of postpartum depression. The most felt was the limitation of family visits during the hospital stay. In addition, the respondents were most concerned about the child's health in both groups. The feeling of loneliness in group I was higher, and basic hope and generalized self-efficacy were lower than in group II. The differences between these relationships were statistically significant.

Well-Being at Home During Forced Quarantine Amid the COVID-19 Pandemic.

Introduction: People recently or currently in forced quarantine or isolation at home have shown high levels of depression and symptoms of generalized anxiety. Aim of the Study: To assess the impact of the COVID-19 pandemic on certain aspects of people's day-to-day functioning. Materials and Methods: The study involved using an online diagnostic survey including a proprietary questionnaire, the DASS 21, and the Liebowitz Social Anxiety Scale. Results: Information about the pandemic in Poland and around the world was systematically obtained by 48.8 and 27.4% of respondents, respectively (N = 1,312). Whereas, 75.6% of respondents declared having knowledge about the number of infected people in Poland, only 28.7% declared having such knowledge about infections worldwide. Most often, respondents had obtained information online (65.9%). According to 45.7% of respondents, infection with COVID-19 is a major threat, and not enough has been done to reduce its spread in Poland (66.7%) or worldwide (56.1%). Respondents considered social distancing (68.3%), quarantining people arriving from abroad (63.4%), and wearing protective masks and/or gloves (60.4%) to be the most effective actions for combatting the pandemic. Most often, in compulsory quarantines, respondents surfed the Internet (48.8%) and experienced a lack of energy or fatigue (40.2%) and anxiety (54.9%). The severity of anxiety (mean = 4.6 points), stress (7.5 points), and depression (7.3 points) were within normal ranges, and the respondents could generally be included in the group showing mildly severe social phobia (57.9 points). Conclusions: Most respondents considered infection with COVID-19 to be a major threat and feared another quarantine. During quarantine, respondents most often experienced fatigue, a lack of energy, nervousness, anxiety, anger, and sadness. Despite demonstrating anxiety, stress, and depression with severity in the normal range, respondents showed no statistically significant correlation between severity and age, gender, place of residence, or level of education. Although they also showed mildly severe social phobia, only gender, not age, place of residence, or level of education, showed a statistically significant correlation with its severity.

The Impact of the COVID-19 Virus Pandemic on the Incidence of First Psychotic Spectrum Disorders

The effects of COVID-19 on the human body are not yet understood enough. Medical history provides information on cases of psychiatric symptoms during viral infections in the 20th century, such as the influenza pandemic. Currently, it is observed that there is an increasing number of new psychiatric disorders in previously healthy individuals. In addition, because of the decreased amount of reporting to health care providers, including psychiatrists, many physicians suggest that the number of neuropsychiatric disorders may be underestimated. In this paper, we review available studies on the occurrence of first-time psychotic spectrum disorder (PSD) in individuals related to SARS-CoV-2 infection. The reviewed studies suggest that first-time psychotic disorder in COVID-19 patients is statistically significantly more frequent compared to influenza, as well as to other respiratory infections. The emergence of new PSDs is explained by direct neurotropism of the virus on the one hand and by immunological mechanisms on the other. The main conclusions of this review should be treated with caution, and future research on this topic is needed. The authors recognize the particular need to develop standardized laboratory panels that include inflammatory markers (IL-6, TNF-α), cerebrospinal fluid (CSF) testing, and SARS-CoV-2 antibody assays to entirely understand the etiology of neuropsychiatric complications of SARS-CoV-2 infections and the pandemic itself. In addition, public health efforts are required to promote mental health, especially during COVID-19.

Increased Depression and Anxiety Disorders during the COVID-19 Pandemic in Children and Adolescents: A Literature Review.

Depression and anxiety disorders are a serious and increasingly commonly diagnosed problem at present. The problem applies not only to adults but also, increasingly often, to children and adolescents as well. The outbreak of the COVID-19 pandemic has further compounded the issue. There are still relatively few publications that show that quarantine and social isolation have a negative effect on the psychological well-being of children and adolescents. Above all, the situation applies to children and adolescents with pre-existing predispositions and to individuals suffering from mental disorders. The key factor in this situation seems to be putting the needs of young people first so that they can safely return to school. It is also important to provide them with effective treatment strategies and methods with which to deal with this stressful and potentially traumatic situation. Most of the mental health research during the COVID-19 pandemic has been conducted in Asia and Europe, where the disease first spread. This article presents an overview of the results of the latest Polish and international studies on the increase in depression and anxiety disorders among children and adolescents during the COVID-19 pandemic worldwide. It concludes with recommendations regarding mental health support for young people, and further directions for treatment are suggested.

First-Time Psychotic Symptoms in a Patient After COVID-19 Infection-A Case Report.

A 39-year-old, previously healthy, white male with no personal or family history of mental illness presented with new, first-time psychotic symptoms. The new psychotic symptoms appeared on patient admission to the hospital, occurring during a diagnosis of symptomatic SARS-CoV-2 infection. On the first day of hospitalization for worsening psychotic symptoms and the appearance of aggression toward the staff, the patient was transferred to the psychiatric hospital. After the initial treatment with antipsychotics and benzodiazepines, his mental condition improved. The patient was then transferred for further treatment of his somatic condition in the internal medicine ward, with a recommendation to continue treatment in the psychiatric ward once his somatic condition was stabilized. This is one of the few reported cases of COVID-19-related psychosis in a patient without a personal or family history; moreover, this description contains important data regarding elevated IL-6, which may prove to be a key factor in the induction of new psychotic symptoms. It indicates the important need for careful monitoring of neuropsychiatric symptoms among COVID-19 patients.

Depressive and Neurocognitive Disorders in the Context of the Inflammatory Background of COVID-19.

The dysfunctional effects of the coronavirus disease 2019 (COVID-19) infection on the nervous system are established. The manifestation of neuropsychiatric symptoms during and after infection is influenced by the neuroinvasive and neurotrophic properties of SARS-CoV-2 as well as strong inflammation characterised by a specific "cytokine storm". Research suggests that a strong immune response to a SARS-CoV-2 infection and psychological stressors related to the pandemic may cause chronic inflammatory processes in the body with elevated levels of inflammatory markers contributing to the intensification of neurodegenerative processes. It is suggested that neuroinflammation and associated central nervous system changes may significantly contribute to the etiopathogenesis of depressive disorders. In addition, symptoms after a COVID-19 infection may persist for up to several weeks after an acute infection as a post-COVID-19 syndrome. Moreover, previous knowledge indicates that among SSRI (selective serotonin reuptake inhibitor) group antidepressants, fluoxetine is a promising drug against COVID-19. In conclusion, further research, observation and broadening of the knowledge of the pathomechanism of a SARS-CoV-2 infection and the impact on potential complications are necessary. It is essential to continue research in order to assess the long-term neuropsychiatric effects in COVID-19 patients and to find new therapeutic strategies.

Biomarkers of Post-COVID Depression.

The COVID-19 pandemic is spreading around the world and 187 million people have already been affected. One of its after-effects is post-COVID depression, which, according to the latest data, affects up to 40% of people who have had SARS-CoV-2 infection. A very important issue for the mental health of the general population is to look for the causes of this complication and its biomarkers. This will help in faster diagnosis and effective treatment of the affected patients. In our work, we focused on the search for major depressive disorder (MDD) biomarkers, which are also present in COVID-19 patients and may influence the development of post-COVID depression. For this purpose, we searched PubMed, Scopus and Google Scholar scientific literature databases using keywords such as 'COVID-19', 'SARS-CoV-2', 'depression', 'post-COVID', 'biomarkers' and others. Among the biomarkers found, the most important that were frequently described are increased levels of interleukin 6 (IL-6), soluble interleukin 6 receptor (sIL-6R), interleukin 1 ß (IL-1ß), tumor necrosis factor α (TNF-α), interferon gamma (IFN-γ), interleukin 10 (IL-10), interleukin 2 (IL-2), soluble interleukin 2 receptor (sIL-2R), C-reactive protein (CRP), Monocyte Chemoattractant Protein-1 (MCP-1), serum amyloid a (SAA1) and metabolites of the kynurenine pathway, as well as decreased brain derived neurotrophic factor (BDNF) and tryptophan (TRP). The biomarkers identified by us indicate the etiopathogenesis of post-COVID depression analogous to the leading inflammatory hypothesis of MDD.